Oxandrolone - Anavar For Women Weight Loss

Oxandrolone, also known as oxandrin, is a drug first synthesized by Raphael Pappo while at Searle Laboratories, now Pfizer Inc., under the trademark Anavar, and introduced into the United States in 1964. It is a synthetic anabolic steroid derivative of dihydrotestosterone with an oxygen atom replacing the 2 carbon and methylation in the 17 position.

Biological effects

Oxandrolone is widely used due to its exceptionally small level of androgenicity accompanied by moderate anabolic effect. Although oxandrolone is a 17-alpha alkyloid, its liver toxicity is very small as well. Studies have shown that a daily dose of 20 mg oxandrolone used in the course of 12 weeks had only a negligible impact on the increase of liver enzymes. As a DHT derivative, oxandrolone does not aromatize, and thus does not cause gynecomastia. It also does not significantly influence the body's normal testosterone production (HPTA axis) at low dosages (20 mg). When dosages are high, the human body reacts by reducing the production of luteinizing hormone after perceiving endogenous testosterone production as too high; this in turn eliminates further stimulation of Leydig cells in the testicles, causing testicular atrophy. Oxandrolone used in a dose of 20 mg/day suppressed endogenous testosterone by 67% after 12 weeks of therapy.

In a randomized, double-blind study, patients with 40% total body surface area burns were selected to receive standard burn care plus oxandrolone, or without oxandrolone. Those treated with oxandrolone showed improved body composition, preserved muscle mass and reduced hospital stay time.

History

The drug was prescribed to promote muscle regrowth in disorders which cause involuntary weight loss, and is used as part of treatment for HIV/AIDS. It had also been shown to be partially successful in treating cases of osteoporosis. However, in part due to bad publicity from its abuses by bodybuilders, production of Anavar was discontinued by Searle Laboratories in 1989. It was picked up by Bio-Technology General Corporation, now Savient Pharmaceuticals who, following successful clinical trials in 1995, released it under the tradename Oxandrin.

It was subsequently approved for orphan drug status by the Food and Drug Administration (FDA) for treating alcoholic hepatitis, Turner syndrome, and HIV-induced weight loss. It is also indicated as an offset to protein catabolism caused by long-term administration of corticosteroids. In addition, the drug has shown positive results in treating anemia and hereditary angioedema. Because of its potential for abuse, it is categorized as a Schedule III controlled substance in the United States.

References

Further reading

External links

• Oxandrin Homepage, savientpharma.com (retrieved 23 October 2009)* Oxandrin Label, fda.gov (retrieved 23 October 2009)
• "Oxandrolone Side Effects, Interactions and Information". drugs.com. 

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